职位描述
We are seeking a highly motivated research investigator in protein sciences to join No-vartis. You will make significant impact on drug discovery projects in early exploratory phase and in discovery pipeline. You will play key roles in target validation, MoA study, and hit validation.
As a member of the Protein Sciences and Structure Biology group, you will work in a dynamic and innovative environment. Your personal growth and career development will contribute to the success of our team. Your major accountabilities include:
• Investigating therapeutic targets by designing and performing protein expres-sion, purification and characterization.
• Providing high quality protein reagents, trouble-shooting and optimizing protein activity, purity and homogeneity for assay development and biostructure studies using various biophysical and biochemical tools.
• Characterizing protein-protein interaction and protein-ligand interaction to vali-date target engagement.
• Developing novel techniques and solutions to challenging scientific questions
Education: Master with 3+ years of experience in protein sciences.
Languages:Business-level oral and written English
Experience/Professional Requirement:
1. Hand-on experiences on recombinant protein construct design and expression. Expertise in multiple insect cell and mammalian expression system.
2. Proficient in different protein purification techniques such as affinity, ion exchange, hydrophobic interaction, gel filtration purification and refolding. Experience on protein-protein or protein-nucleic acid complex is a plus.
3. Knowledgeable and skillful in protein characterization and protein-ligand interaction using various biophysical methods. Hand-on experience on SPR is a must. Motivated to expand your skill sets including DSF, SEC-MALS, ITC, MST, AUC, LC/MSMS, etc.
4. Background in protein crystallography, bio-NMR or cryo-EM is preferred.
5. Demonstrated critical thinking and trouble-shooting ability when handling challenging proteins such as aggregated protein, multicomponent complex, or membrane protein.
6. Passionate about biomedical research and drug discovery. A team worker with excellent communication skills.
企业介绍
作为诺华全球药物研发网络的一部分,诺华(中国)生物医学研究中心(CNIBR)于2007 年正式投入运营,成为跨国医药健康企业在华建立的首家、也是规模最大的综合性研发中心。通过多年发展,研发中心成为诺华生物医学研究中心(NIBR)在亚太地区的重要基地,依托自身在新药研发领域的强大实力,通过各种形式的合作与交流惠及包括韩国、日本、台湾在内的多个国家和地区的医药研发。研发中心扎根上海,旨在通过与本土生命科学研究机构广泛开展合作,引领区域性创新新药研发。